Description

(3-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)-4,5-Difluorophenyl)Boronic Acid is a sophisticated boronic acid derivative and a key building block in modern pharmaceutical synthesis. This compound is specifically engineered for use in cross-coupling reactions, most notably the Suzuki-Miyaura reaction, which is fundamental for constructing complex carbon-carbon bonds. It is an essential intermediate for medicinal chemistry researchers and process development scientists working on novel drug candidates, particularly in the areas of kinase inhibitors and other small molecule therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially in oncology and CNS research.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for the palladium-catalyzed formation of biaryl and heterobiaryl structures.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to optimize lead compounds.
• Process Chemistry & Scale-up: Employed in the development of robust, scalable synthetic routes for advanced intermediates under GMP-like conditions.
• Chemical Biology Probes: Utilized in the creation of molecular probes for target identification and validation in biological systems.
• Agrochemical Research: Potential intermediate in the research and development of novel crop protection agents.

Basic Information

Product Name	(3-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)-4,5-Difluorophenyl)Boronic Acid
CAS No.	1704067-25-3
Molecular Formula	C15H21BF2N2O4
Molecular Weight	342.15 g/mol
Synonyms	4,5-Difluoro-3-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]benzeneboronic Acid; Boc-Piperazinyl-Difluorophenylboronic Acid; 3-(4-Boc-Piperazin-1-yl)-4,5-difluorophenylboronic Acid; (3-(4-(Boc)Piperazin-1-yl)-4,5-difluorophenyl)boronic Acid; N-Boc-4-(4,5-difluoro-3-boronophenyl)piperazine; tert-Butyl 4-(4,5-difluoro-3-boronophenyl)piperazine-1-carboxylate; Boc-Protected Difluorophenylboronic Acid Piperazine Derivative
EINECS	Contact for details

Quality Control

Our (3-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)-4,5-Difluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with GMP starting material expectations upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Assay	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.