Description

(3,4-Difluoro-5-Morpholinophenyl)Boronic Acid is a high-value boronic acid derivative and a key synthetic intermediate in modern organic chemistry. Its primary commercial value lies in its role as a versatile building block for the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for forming carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients. The morpholino and difluoro substitutions impart specific electronic and steric properties, making it crucial for constructing complex, functionalized biaryl and heterobiaryl structures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used to construct novel herbicide and fungicide molecules, where the fluorine atoms and morpholine ring can enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or linker for creating advanced organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and as a scaffold for probe molecules in chemical biology.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	(3,4-Difluoro-5-Morpholinophenyl)Boronic Acid
CAS No.	1704067-18-4
Molecular Formula	C10H12BF2NO3
Molecular Weight	243.02 g/mol
Synonyms	5-Morpholino-3,4-difluorobenzeneboronic acid; (3,4-Difluoro-5-morpholin-4-ylphenyl)boronic acid; 3,4-Difluoro-5-morpholinophenylboronic acid; B-(3,4-Difluoro-5-morpholinophenyl)boronic acid; 1704067-18-4; 3,4-Difluoro-5-morpholinobenzene-1-boronic acid; AKOS026712293; FT-0698397
EINECS	Contact for details

Quality Control

Our (3,4-Difluoro-5-Morpholinophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent industry standards. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring traceability and consistency for demanding pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.