Description

3-(tert-Butoxymethyl)-4-Fluorophenylboronic Acid is a specialized organoboron compound featuring a fluorinated aromatic ring and a tert-butoxymethyl protecting group. This structural combination makes it a valuable high-purity building block for advanced organic synthesis, particularly in cross-coupling reactions. It is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in medicinal chemistry programs targeting CNS and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atom and boronic acid group enable precise structural modifications.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for the production of bespoke compounds and complex multi-step syntheses.

Basic Information

Product Name	3-(tert-Butoxymethyl)-4-Fluorophenylboronic Acid
CAS No.	1704067-02-6
Molecular Formula	C₁₁H₁₆BFO₃
Molecular Weight	226.05 g/mol
Synonyms	4-Fluoro-3-((2-methylpropan-2-yl)oxy)methyl)benzeneboronic Acid; [3-[(1,1-Dimethylethoxy)methyl]-4-fluorophenyl]boronic Acid; 3-(tert-Butoxymethyl)-4-fluorobenzeneboronic Acid; 4-Fluoro-3-(tert-butoxymethyl)phenylboronic Acid; 3-(tert-Butyloxymethyl)-4-fluorophenylboronic Acid; 3-(tert-Butoxymethyl)-4-Fluorophenylboronic Acid Pinacol Ester (common derivative); B-[3-[(1,1-Dimethylethoxy)methyl]-4-fluorophenyl]-Boronic Acid
EINECS	Contact for details

Quality Control

Our production of 3-(tert-Butoxymethyl)-4-Fluorophenylboronic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.