Description

(4,5-Difluoro-2-(Pyrrolidin-1-Ylsulfonyl)Phenyl)Boronic Acid is a high-value, multi-functional organoboron building block characterized by its unique difluoro-substituted phenyl ring and pyrrolidine sulfonyl moiety. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for creating complex carbon-carbon bonds. It is primarily utilized by pharmaceutical R&D and agrochemical scientists for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the discovery and synthesis of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Serves as a precursor for creating advanced organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for studying biological processes and target engagement.
• Academic & Contract Research: A valuable reagent for methodology development and complex molecule synthesis in academic and industrial research laboratories.
• Custom Synthesis & Scale-up: Supplied for custom synthesis projects, from milligram-scale discovery to multi-kilogram process development.

Basic Information

Product Name	(4,5-Difluoro-2-(Pyrrolidin-1-Ylsulfonyl)Phenyl)Boronic Acid
CAS No.	1704066-91-0
Molecular Formula	C10H12BF2NO4S
Molecular Weight	299.08 g/mol
Synonyms	(4,5-Difluoro-2-(pyrrolidine-1-sulfonyl)phenyl)boronic acid; 2-(Pyrrolidin-1-ylsulfonyl)-4,5-difluorophenylboronic acid; 4,5-Difluoro-2-(pyrrolidine-1-sulfonyl)benzeneboronic acid; Boronic acid, B-[4,5-difluoro-2-(1-pyrrolidinylsulfonyl)phenyl]-; CAS 1704066-91-0; Difluoro (pyrrolidinesulfonyl) phenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of our (4,5-Difluoro-2-(Pyrrolidin-1-Ylsulfonyl)Phenyl)Boronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. Certificates of Analysis (COA) detailing purity (by HPLC/NMR), identity confirmation, and impurity profiles are available for all shipments. Our quality protocols are designed to support cGMP and ISO compliant workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon/nitrogen) for long-term storage or after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.