Description

3-(Ethoxymethyl)-4-Fluorophenylboronic Acid is a specialized organoboron compound featuring both a fluorinated aromatic ring and an ethoxymethyl substituent, making it a versatile building block for modern synthetic chemistry. This boronic acid derivative is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated biphenyl or heterobiaryl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Employed in creating novel herbicides, fungicides, and insecticides where the fluorophenyl group contributes to target specificity and environmental persistence.
• Material Science Research: Used in the development of organic electronic materials, such as ligands for OLEDs and OFETs, where precise molecular architecture is required.
• Chemical Biology & Probe Development: Serves as a building block for fluorescent tags, enzyme inhibitors, and other molecular probes used in diagnostic and biochemical research.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for CROs and CDMOs specializing in providing bespoke chemical entities for client R&D programs.

Basic Information

Product Name	3-(Ethoxymethyl)-4-Fluorophenylboronic Acid
CAS No.	1704066-77-2
Molecular Formula	C9H12BFO3
Molecular Weight	197.99 g/mol
Synonyms	4-Fluoro-3-(ethoxymethyl)benzeneboronic Acid; (4-Fluoro-3-(ethoxymethyl)phenyl)boronic Acid; 3-(Ethoxymethyl)-4-fluorobenzeneboronic Acid; B-[4-Fluoro-3-(ethoxymethyl)phenyl]boronic Acid; 1704066-77-2; 4-Fluoro-3-ethoxymethylphenylboronic Acid
EINECS	Contact for details

Quality Control

Every batch of 3-(Ethoxymethyl)-4-Fluorophenylboronic Acid is manufactured under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling reactions. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality systems are designed to support cGMP and ISO compliant workflows for advanced R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.