Description

5-Fluorine-2-((4-Methylpiperazin-1-Yl)Methyl)Phenylboronatehydrochloride is a high-purity, advanced pharmaceutical intermediate and building block. This compound is of significant value for its role in modern synthetic chemistry, particularly in the development of novel active pharmaceutical ingredients (APIs) and complex organic molecules. It is primarily needed by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in drug discovery, process chemistry, and the synthesis of boron-containing compounds.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key organoboron reagent for forming carbon-carbon bonds, a fundamental transformation in medicinal chemistry and material science.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linker components and warhead ligands for targeted protein degradation therapeutics.
• Kinase Inhibitor Research: Employed in the synthesis of novel kinase inhibitor scaffolds for cancer and inflammatory disease research.
• Chemical Biology & Probe Development: Utilized to create chemical probes for studying biological pathways and protein function.
• Process Research & Development (R&D): Serves as a starting material or intermediate in the scale-up and optimization of API manufacturing processes.

Basic Information

Product Name	5-Fluorine-2-((4-Methylpiperazin-1-Yl)Methyl)Phenylboronatehydrochloride
CAS No.	1704065-33-7
Molecular Formula	C13H19BFN2O2 • HCl
Molecular Weight	312.57 g/mol (Free base: 275.11 g/mol)
Synonyms	(5-Fluoro-2-((4-methylpiperazin-1-yl)methyl)phenyl)boronic acid hydrochloride; 2-Fluoro-5-((4-methylpiperazin-1-yl)methyl)phenylboronic acid HCl; 5-Fluoro-2-((4-methyl-1-piperazinyl)methyl)benzeneboronic acid hydrochloride; B-(5-Fluoro-2-((4-methyl-1-piperazinyl)methyl)phenyl)boronic acid hydrochloride; CAS 1704065-33-7; Boronic acid, B-[5-fluoro-2-[(4-methyl-1-piperazinyl)methyl]phenyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 5-Fluorine-2-((4-Methylpiperazin-1-Yl)Methyl)Phenylboronatehydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.