Description

(2-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-5-Fluorophenyl)Boronic Acid CAS NO 1704064-29-8 is a sophisticated boronic acid derivative featuring a protected piperazine moiety, designed for advanced synthetic applications. This compound is a critical building block in modern pharmaceutical research, enabling the precise construction of complex molecules through reliable cross-coupling reactions. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel drug candidates, particularly in targeted therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology, CNS, and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for constructing biaryl and heterobiaryl scaffolds central to many drug molecules.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the synthesis of linker components and E3 ligase ligands for targeted protein degradation platforms.
• Peptidomimetic & Macrocycle Synthesis: The tert-butoxycarbonyl (Boc)-protected piperazine acts as a versatile nitrogen-containing building block for constructing constrained peptides and macrocyclic compounds.
• Chemical Biology Probe Development: Employed in the creation of tool compounds and molecular probes for studying biological pathways and target validation.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for drug discovery campaigns.

Basic Information

Product Name	(2-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-5-Fluorophenyl)Boronic Acid
CAS No.	1704064-29-8
Molecular Formula	C₁₇H₂₆BFN₂O₄
Molecular Weight	352.21 g/mol
Synonyms	(2-((4-(Boc)Piperazin-1-Yl)Methyl)-5-Fluorophenyl)Boronic Acid; 2-[(4-{[(tert-Butoxy)carbonyl]amino}piperazin-1-yl)methyl]-5-fluorobenzeneboronic acid; 5-Fluoro-2-((4-(N-Boc-piperazin-1-yl)methyl)phenylboronic acid; Boc-Piperazine-Boronic Acid Derivative; 1-Boc-4-((2-Borono-4-fluorobenzyl))piperazine; 4-(tert-Butoxycarbonyl)-1-((2-borono-4-fluorophenyl)methyl)piperazine
EINECS	Contact for details

Quality Control

Our (2-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-5-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete analytical data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.