Description

(2-Fluoro-4-((2,2,2-Trifluoroethoxy)Methyl)Phenyl)Boronic Acid is a high-purity, advanced pharmaceutical intermediate and key building block in modern synthetic chemistry. This compound is specifically engineered for use in cross-coupling reactions, most notably the Suzuki-Miyaura reaction, which is fundamental to constructing complex molecules in drug discovery and materials science. It is an essential reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable boron-containing synthons.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: A premier reagent for forming carbon-carbon bonds, enabling the construction of complex biaryl and heterobiaryl structures prevalent in modern medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require fluorinated aromatic components for enhanced activity and stability.
• Materials Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors, where fluorination improves performance.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and enzyme inhibitors for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	(2-Fluoro-4-((2,2,2-Trifluoroethoxy)Methyl)Phenyl)Boronic Acid
CAS No.	1704064-28-7
Molecular Formula	C9H9BF4O3
Molecular Weight	252.0 g/mol
Synonyms	[2-Fluoro-4-[(2,2,2-trifluoroethoxy)methyl]phenyl]boronic acid; 2-Fluoro-4-((2,2,2-trifluoroethoxy)methyl)benzeneboronic acid; 4-(2,2,2-Trifluoroethoxymethyl)-2-fluorophenylboronic acid; B-[2-Fluoro-4-[(2,2,2-trifluoroethoxy)methyl]phenyl]boronic acid; (2-Fluoro-4-((2,2,2-trifluoroethoxy)methyl)phenyl)boronic acid; Boronic acid, B-[2-fluoro-4-[(2,2,2-trifluoroethoxy)methyl]phenyl]-; 1704064-28-7
EINECS	Contact for details

Quality Control

Our (2-Fluoro-4-((2,2,2-Trifluoroethoxy)Methyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent lot-to-lot performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.