Description

(4-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-2-Fluorophenyl)Boronic Acid is a sophisticated boronic acid derivative and a key building block in modern pharmaceutical synthesis. This compound matters because it combines a protected piperazine moiety with a boronic acid functional group, enabling critical carbon-carbon bond formation and serving as a versatile intermediate for targeted drug discovery. It is primarily needed by research chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS therapeutic areas.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a boronic acid reagent for the palladium-catalyzed formation of biaryl bonds, a cornerstone reaction in medicinal chemistry.
• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those containing fluorinated aromatic and piperazine-based structures.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the synthesis of linker components or warhead ligands for targeted protein degradation platforms.
• Kinase Inhibitor Synthesis: Building block for the creation of potent and selective kinase inhibitors, a major class of oncology therapeutics.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and protein-protein interactions.
• Process Research & Scale-Up: Serves as a high-purity intermediate for optimizing synthetic routes from laboratory to pilot and commercial scale.

Basic Information

Product Name	(4-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-2-Fluorophenyl)Boronic Acid
CAS No.	1704064-25-4
Molecular Formula	C17H26BFN2O4
Molecular Weight	352.21 g/mol
Synonyms	(4-((4-(tert-Butoxycarbonyl)piperazin-1-yl)methyl)-2-fluorophenyl)boronic acid; 2-Fluoro-4-[(4-{[(tert-butoxy)carbonyl]amino}piperazin-1-yl)methyl]benzeneboronic acid; Boc-Piperazinylmethyl-Fluorophenylboronic Acid; 1-Boc-4-[(4-Borono-3-fluorobenzyl)piperazine]; 4-(1-Boc-piperazin-4-ylmethyl)-2-fluorobenzeneboronic acid; N-Boc-4-(2-Fluoro-4-boronobenzyl)piperazine; 1704064-25-4; Contact for EINECS details.

Quality Control

Our (4-((4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Methyl)-2-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.