Description

(3-(((tert-Butoxycarbonyl)(Cyclopropyl)Amino)Methyl)-5-Fluorophenyl)Boronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected amine group with a boronic acid moiety, making it an essential reagent for cross-coupling reactions like the Suzuki-Miyaura reaction. This high-purity intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of complex, nitrogen-containing heterocycles and targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing fluorinated aromatic and cyclopropylamine motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for constructing biaryl and heterobiaryl structures central to many drug discovery programs.
• Protected Amine Synthon: The tert-butoxycarbonyl (Boc) protected cyclopropylamine group allows for selective deprotection and further functionalization in multi-step synthetic routes.
• Medicinal Chemistry Research: Used in library synthesis for structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic properties.
• Ligand and Catalyst Development: Potential building block for creating novel ligands or organocatalysts due to its unique steric and electronic profile.
• Material Science Precursor: Can be utilized in the development of organic electronic materials or metal-organic frameworks (MOFs) requiring specific functional group integration.

Basic Information

Product Name	(3-(((tert-Butoxycarbonyl)(Cyclopropyl)Amino)Methyl)-5-Fluorophenyl)Boronic Acid
CAS No.	1704063-72-8
Molecular Formula	C16H23BFNO4
Molecular Weight	323.17 g/mol
Synonyms	(3-(((tert-Butoxycarbonyl)(cyclopropyl)amino)methyl)-5-fluorophenyl)boronic acid; (3-((N-Boc-N-cyclopropylamino)methyl)-5-fluorophenyl)boronic acid; Boc-cyclopropylamino-methyl-5-fluorophenylboronic acid; (3-((N-Boc-cyclopropylamino)methyl)-5-fluorophenyl)boronic acid; 5-Fluoro-3-((N-Boc-cyclopropylamino)methyl)benzeneboronic acid; N-Boc-N-cyclopropyl-3-(5-fluoro-3-boronobenzyl)amine; 1704063-72-8
EINECS	Contact for details

Quality Control

Our (3-(((tert-Butoxycarbonyl)(Cyclopropyl)Amino)Methyl)-5-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container sealed under an inert atmosphere to maintain stability and prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.