Description

Methyl(2S)-2-Amino-2-[3-Fluoro-4-(Trifluoromethoxy)Phenyl]Acetate is a high-purity, non-natural amino acid derivative featuring a chiral center and a unique trifluoromethoxy-substituted aromatic ring. This compound is a critical advanced pharmaceutical intermediate (API) designed for the synthesis of complex, biologically active molecules. It is essential for research and development chemists in the pharmaceutical and agrochemical industries who require building blocks with specific stereochemistry and fluorinated motifs to modulate the potency, metabolic stability, and bioavailability of new drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and metabolic disease research.
• Peptidomimetics Synthesis: Used to incorporate non-natural amino acid residues into peptide chains to enhance stability against enzymatic degradation and improve pharmacological properties.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides where the fluorine and trifluoromethoxy groups contribute to lipophilicity and target binding.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands for asymmetric catalysis and in organometallic chemistry due to its defined stereochemistry and functional groups.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high stereochemical purity and fluorinated aromatic systems.

Basic Information

Product Name	Methyl(2S)-2-Amino-2-[3-Fluoro-4-(Trifluoromethoxy)Phenyl]Acetate
CAS No.	1703935-54-9
Molecular Formula	C10H9F4NO3
Molecular Weight	267.18 g/mol
Synonyms	(S)-Methyl 2-amino-2-(3-fluoro-4-(trifluoromethoxy)phenyl)acetate; L-2-Amino-2-(3-fluoro-4-(trifluoromethoxy)phenyl)acetic acid methyl ester; Methyl (S)-2-amino-2-(3-fluoro-4-(trifluoromethoxyphenyl)acetate; 2-Amino-2-(3-fluoro-4-(trifluoromethoxy)phenyl)acetic acid methyl ester, (2S)-; Methyl L-α-amino-3-fluoro-4-(trifluoromethoxy)benzeneacetate; (S)-α-Amino-3-fluoro-4-(trifluoromethoxy)benzeneacetic acid methyl ester; 1703935-54-9; Methyl (2S)-2-amino-2-(3-fluoro-4-(trifluoromethoxyphenyl)acetate
EINECS	Contact for details

Quality Control

Our production of Methyl(2S)-2-Amino-2-[3-Fluoro-4-(Trifluoromethoxy)Phenyl]Acetate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure consistent high purity and chemical identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. Our quality system is designed to support cGMP requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is compatible with strong alkali/organic solvents; ensure storage areas are free from incompatible materials. Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.