Description

Rac 7-Hydroxy Efavirenz 7-o-β-D-Glucuronide is a key glucuronide metabolite of the antiretroviral drug Efavirenz. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in anti-HIV drug development and bioanalytical method validation.

Application

• Metabolite Reference Standard: Serves as a critical certified reference material (CRM) for the quantification and identification of Efavirenz metabolites in biological matrices during preclinical and clinical studies.
• Pharmacokinetic & DMPK Studies: Used to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of Efavirenz, aiding in understanding its in vivo behavior and potential drug-drug interactions.
• Bioanalytical Method Development: Essential for developing and validating sensitive and specific HPLC-MS/MS or LC-MS methods for therapeutic drug monitoring and regulatory bioanalysis.
• Impurity Profiling: Employed as an impurity marker in the quality control of Efavirenz active pharmaceutical ingredient (API) to ensure product safety and compliance with ICH guidelines.
• Enzyme Activity Assays: Utilized in vitro to study the activity and kinetics of UDP-glucuronosyltransferase (UGT) enzymes responsible for its formation.
• Toxicology Research: Supports studies investigating the role of metabolites in the efficacy and potential side-effect profile of Efavirenz-based therapies.

Basic Information

Product Name	Rac 7-Hydroxy Efavirenz 7-o-β-D-Glucuronide
CAS No.	1702668-46-9
Molecular Formula	C24H27F3NO10
Molecular Weight	546.47 g/mol
Synonyms	7-Hydroxyefavirenz 7-O-β-D-glucuronide; Efavirenz 7-O-Glucuronide; (±)-7-Hydroxyefavirenz 7-O-β-D-glucopyranosiduronic acid; 8-Chloro-5-(2-cyclopropylethynyl)-5-hydroxy-4-(4-(((2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((1S)-2-methoxy-1-(trifluoromethyl)vinyl)oxy)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3,5-dihydro-2H-benzo[e][1,4]diazepin-2-one; EFV 7-O-Glucuronide
EINECS	Contact for details

Quality Control

Our high-purity reference standards are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, LC-MS, and NMR to confirm identity and purity, ensuring compliance with the requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. For long-term storage under inert atmosphere, sealing under argon or nitrogen is recommended. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.