Description

8-Fluoro-2,3-Dihydro-1,4-Benzoxazine-6-Boronic Acid is a high-value, multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex heterocyclic compounds, particularly in the research and development of new active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides by constructing specific fluorinated benzoxazine scaffolds.
• Material Science Research: Employed in the development of advanced organic electronic materials, such as OLEDs and organic semiconductors, due to its fused heterocyclic structure.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura cross-coupling to form carbon-carbon bonds, enabling the modular assembly of complex molecular architectures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organoboron catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Used to synthesize molecular probes for studying biological processes and enzyme functions.

Basic Information

Product Name	8-Fluoro-2,3-Dihydro-1,4-Benzoxazine-6-Boronic Acid
CAS No.	1701449-28-6
Molecular Formula	C8H9BFO3
Molecular Weight	183.97 g/mol
Synonyms	6-Borono-8-fluoro-2,3-dihydro-1,4-benzoxazine; (8-Fluoro-2,3-dihydro-1,4-benzoxazin-6-yl)boronic acid; 8-Fluoro-2,3-dihydro-4H-1,4-benzoxazine-6-boronic acid; 8-Fluoro-3,4-dihydro-2H-1,4-benzoxazine-6-boronic acid; 1701449-28-6; 8-Fluoro-2,3-dihydro-1,4-benzoxazine-6-boronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Our 8-Fluoro-2,3-Dihydro-1,4-Benzoxazine-6-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. For long-term storage, consider storing under an inert gas in a freezer (-20°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.