Description

2-Benzyloxy-4-(Trifluoromethyl)Phenylboronic Acid is a high-purity, advanced pharmaceutical intermediate and versatile synthetic building block. This compound is valued for its unique molecular structure, which combines a boronic acid functional group with a benzyl-protected phenol and a trifluoromethyl substituent, enabling precise cross-coupling reactions. It is primarily sought after by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex biaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the stability imparted by the trifluoromethyl group.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and inhibitors for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific boronic acid derivatives.

Basic Information

Product Name	2-Benzyloxy-4-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1701435-39-3
Molecular Formula	C14H12BF3O3
Molecular Weight	296.05 g/mol
Synonyms	[2-(Benzyloxy)-4-(trifluoromethyl)phenyl]boronic acid; 2-(Benzyloxy)-4-(trifluoromethyl)benzeneboronic acid; B-[2-(Phenylmethoxy)-4-(trifluoromethyl)phenyl]boronic acid; (2-Benzyloxy-4-trifluoromethylphenyl)boronic acid; 2-Benzyloxy-α,α,α-trifluoro-p-tolylboronic acid; 4-Trifluoromethyl-2-benzyloxyphenylboronic Acid; Boronic acid, B-[2-(phenylmethoxy)-4-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 2-Benzyloxy-4-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.