Description

1-{[(tert-Butoxy)Carbonyl]Amino-3-Methoxycyclobutane-1-Carboxylic Acid CAS NO 1700442-25-6 is a high-purity, protected amino acid derivative featuring a cyclobutane ring, a tert-butoxycarbonyl (Boc) protecting group, and a methoxy substituent. This compound is a critical building block in modern organic synthesis, particularly valued for its role in constructing complex, conformationally constrained molecules. It is primarily needed by pharmaceutical research and development teams, medicinal chemists, and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and peptide mimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Peptidomimetics & Constrained Peptides: Used to introduce a rigid, cyclobutane scaffold into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Protease Inhibitor Development: Serves as a core structure or precursor in the design of inhibitors for various proteolytic enzymes.
• Chemical Biology Probes: Employed in the construction of molecular probes for studying enzyme function and protein-protein interactions.
• Academic & Contract Research: Utilized in research laboratories for methodological development in asymmetric synthesis and heterocyclic chemistry.
• Custom Synthesis & Scale-Up: A starting material for contract manufacturing organizations (CMOs) producing custom APIs under cGMP guidelines.

Basic Information

Product Name	1-{[(tert-Butoxy)Carbonyl]Amino-3-Methoxycyclobutane-1-Carboxylic Acid
CAS No.	1700442-25-6
Molecular Formula	C12H21NO5
Molecular Weight	259.30 g/mol
Synonyms	1-((tert-Butoxycarbonyl)amino)-3-methoxycyclobutane-1-carboxylic acid; 1-(Boc-amino)-3-methoxycyclobutane-1-carboxylic acid; 1-N-Boc-amino-3-methoxycyclobutane-1-carboxylic acid; Boc-3-Methoxycyclobutylglycine; (1-((tert-Butoxycarbonyl)amino)-3-methoxycyclobutyl)formic acid; 3-Methoxy-1-((((2-methylpropan-2-yl)oxy)carbonyl)amino)cyclobutane-1-carboxylic acid; BCMA; 1700442-25-6
EINECS	Contact for details

Quality Control

Our production of 1-{[(tert-Butoxy)Carbonyl]Amino-3-Methoxycyclobutane-1-Carboxylic Acid adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, supporting traceability and compliance with research and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.