Description

3-Ethynyl-1,1-Difluorocyclobutane is a specialized fluorinated cyclobutane derivative featuring a reactive ethynyl group. This compound is valued as a versatile and high-value building block in advanced organic synthesis, enabling the introduction of both strained ring and fluorine motifs into target molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in medicinal chemistry and functional material design.

Application

• Pharmaceutical Intermediate: A key synthon for constructing novel drug candidates, particularly in fragment-based drug discovery and for creating fluorinated bioactive molecules.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides where the fluorinated cyclobutane structure can enhance biological activity and environmental stability.
• Advanced Material Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, resins, and coatings with tailored thermal or chemical resistance properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands or metal-organic frameworks (MOFs) with unique electronic and steric properties.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the properties of strained fluorocarbons.
• Click Chemistry Substrate: The terminal alkyne group makes it suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, useful in bioconjugation and polymer science.

Basic Information

Product Name	3-Ethynyl-1,1-Difluorocyclobutane
CAS No.	1698054-36-2
Molecular Formula	C6H6F2
Molecular Weight	116.11 g/mol
Synonyms	1,1-Difluoro-3-ethynylcyclobutane; 3-Ethynyl-1,1-difluorocyclobutane; Difluoro(ethynyl)cyclobutane; Ethynyl-1,1-difluorocyclobutane; 1,1-Difluoro-3-ethynyl-cyclobutane
EINECS	Contact for details

Quality Control

Our 3-Ethynyl-1,1-Difluorocyclobutane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, GC analysis, and NMR confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its highly volatile nature, keep the container tightly sealed when not in use and store at recommended room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.