Description

5-(2-Hydroxyethyl)Nicotinonitrile is a versatile nitrile-functionalized pyridine derivative that serves as a critical building block in advanced organic synthesis. Its bifunctional structure, featuring both a reactive nitrile group and a hydroxymethyl side chain, makes it a valuable intermediate for constructing complex molecular architectures. This compound is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Building block for developing new-generation pesticides and herbicides with improved efficacy and selectivity.
• Ligand and Catalyst Development: Used to create specialized ligands for metal catalysis and organocatalysts in asymmetric synthesis.
• Functional Material Research: Intermediate in the production of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Serves as a scaffold for creating molecular probes and tags used in biochemical and cellular research.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development of scalable synthetic routes.

Basic Information

Product Name	5-(2-Hydroxyethyl)Nicotinonitrile
CAS No.	1694868-89-7
Molecular Formula	C8H8N2O
Molecular Weight	148.16 g/mol
Synonyms	3-Cyano-5-(2-hydroxyethyl)pyridine; 5-(2-Hydroxyethyl)-3-pyridinecarbonitrile; 3-Pyridinecarbonitrile, 5-(2-hydroxyethyl)-; Nicotinonitrile, 5-(2-hydroxyethyl)-; 5-(2-Hydroxyethyl)pyridine-3-carbonitrile; 2-(3-Cyanopyridin-5-yl)ethanol; 5-(β-Hydroxyethyl)nicotinonitrile
EINECS	Contact for details

Quality Control

Our 5-(2-Hydroxyethyl)Nicotinonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.