Description

Alkyne Tyramide CAS NO 1694495-59-4 is a specialized tyramide derivative functionalized with an alkyne group, enabling its use as a critical reagent in advanced bio-conjugation and labeling techniques. This compound is essential for researchers and developers requiring high-precision molecular tagging for detection and analysis. It is primarily utilized in the life sciences sector for applications in immunohistochemistry, in situ hybridization, and the development of novel diagnostic assays.

Application

• Signal Amplification in IHC/ISH: Used as a tyramide signal amplification (TSA) reagent for highly sensitive detection of low-abundance targets in tissue and cell samples.
• Bioorthogonal Labeling: The alkyne handle allows for efficient, specific conjugation via click chemistry (e.g., CuAAC) with azide-modified probes, dyes, or other molecules.
• Multiplexed Imaging: Enables sequential labeling protocols for visualizing multiple biomarkers within a single sample, crucial for complex disease research.
• Diagnostic Assay Development: Serves as a key component in the fabrication of sensitive and specific clinical diagnostic tests and kits.
• Proteomics & Biomarker Discovery: Facilitates the tagging and isolation of specific proteins or protein complexes for mass spectrometry analysis.
• Nucleic Acid Detection: Applied in fluorescence in situ hybridization (FISH) and related techniques for genomic and transcriptomic visualization.

Basic Information

Product Name	Alkyne Tyramide
CAS No.	1694495-59-4
Molecular Formula	C11H11NO2
Molecular Weight	189.21 g/mol
Synonyms	N-(4-Hydroxyphenethyl)propiolamide; Tyramide Alkyne; p-Hydroxyphenethylpropiolamide; Alkyne-Tyramide; Click Chemistry Tyramide; TSA Alkyne Reagent; Tyramide-PEG-Alkyne; Propargyl Tyramide
EINECS	Contact for details

Quality Control

Every batch of Alkyne Tyramide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and performance consistency. Our quality system is designed to meet the exacting requirements of research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.