Description

1,3,2-Dioxaborolane, 2-[2-Methoxy-4-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl- is a high-purity, advanced boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in providing a stable, protected boronic acid equivalent that facilitates complex cross-coupling reactions with high efficiency and selectivity. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality intermediates for developing novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heterobiaryl scaffolds prevalent in pharmaceutical candidates.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas.
• Agrochemical Synthesis: Employed in creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Materials Science Research: A precursor for organic electronic materials, including OLEDs and organic semiconductors.
• Chemical Biology & Probe Development: Utilized for labeling and modifying biomolecules in drug discovery research.
• Process Chemistry & Scale-up: Offers a stable, handling-friendly alternative to sensitive boronic acids in large-scale manufacturing.

Basic Information

Item	Details
Product Name	1,3,2-Dioxaborolane, 2-[2-Methoxy-4-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-
CAS No.	1689547-84-9
Molecular Formula	C14H18BF3O3
Molecular Weight	302.10 g/mol
Synonyms	2-(2-Methoxy-4-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-[2-methoxy-4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane; 2-Methoxy-4-(trifluoromethyl)phenylboronic acid pinacol ester; (2-Methoxy-4-(trifluoromethyl)phenyl)boronic acid pinacol ester; Pinacol [2-methoxy-4-(trifluoromethyl)phenyl]boronate
EINECS	Contact for details

Quality Control

Every batch of our 1,3,2-Dioxaborolane derivative is manufactured and tested under strict quality management systems to ensure exceptional purity and batch-to-batch consistency. Our products undergo rigorous analytical testing, including NMR, HPLC, and GC, to confirm identity and purity, meeting the stringent requirements for advanced synthetic intermediates. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.