Description

2-Methyl-4-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound matters as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex molecules for advanced materials and pharmaceuticals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel compounds with specific functionalities.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A critical reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethyl-substituted aromatic systems.
• Agrochemical Synthesis: Serves as a building block for novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where its structural motif can tune electronic properties.
• Ligand and Catalyst Development: Used to synthesize novel ligands for transition metal catalysis.
• Chemical Biology Probes: Acts as a precursor for labeling reagents and molecular probes used in biochemical research.

Basic Information

Product Name	2-Methyl-4-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester
CAS No.	1689509-92-9
Molecular Formula	C14H18BF3O2
Molecular Weight	286.10 g/mol
Synonyms	2-Methyl-4-(trifluoromethyl)benzeneboronic acid pinacol ester; (2-Methyl-4-(trifluoromethyl)phenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[2-methyl-4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane; 2-(2-Methyl-4-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol [2-Methyl-4-(trifluoromethyl)phenyl]boronate; Boronic acid, B-[2-methyl-4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester (9CI); 2-Methyl-α,α,α-trifluoro-p-tolueneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Methyl-4-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
NMR Purity (1H, 13C, 11B)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.