Description

2-Chloro-6-Fluoro-3-Methylphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial protected boronic acid building block, offering enhanced stability and handling characteristics compared to its free acid form. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced cross-coupling reactions, such as the Suzuki-Miyaura reaction, to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific halogenated aryl motifs.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysts, and novel polymers.
• Chemical Biology & Diagnostics: Acts as a precursor for probes and labeling reagents used in biochemical assays and imaging.
• Process Chemistry & Scale-up: Preferred in large-scale manufacturing due to its improved stability and solubility profile over the corresponding boronic acid.
• Academic & Contract Research: Essential reagent for methodological development and complex molecule synthesis in academic and CRO laboratories.

Basic Information

Item	Details
Product Name	2-Chloro-6-Fluoro-3-Methylphenylboronic Acid Pinacol Ester
CAS No.	1688672-06-1
Molecular Formula	C₁₃H₁₇BClFO₂
Molecular Weight	269.54 g/mol
Synonyms	2-Chloro-6-fluoro-3-methylbenzeneboronic acid pinacol ester; (2-Chloro-6-fluoro-3-methylphenyl)boronic acid pinacol ester; Pinacol (2-chloro-6-fluoro-m-tolyl)boronate; B-(2-Chloro-6-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Chloro-6-fluoro-3-methylphenylboronic acid, pinacol ester; 1688672-06-1; Boronic acid, B-(2-chloro-6-fluoro-3-methylphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluoro-3-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent hydrolysis. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.