Description

2-Methoxy-5-Trifluoromethoxyphenylboronic Acid Pinacol Ester is a high-value, advanced boronic ester building block crucial for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in enabling the precise and efficient construction of complex molecules, which is essential for developing new active compounds. This intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel drug candidates, crop protection agents, and functional organic materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Serves as a building block for creating advanced organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical raw material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Methoxy-5-Trifluoromethoxyphenylboronic Acid Pinacol Ester
CAS No.	1688666-59-2
Molecular Formula	C14H18BF3O4
Molecular Weight	318.10 g/mol
Synonyms	2-Methoxy-5-(trifluoromethoxy)phenylboronic acid pinacol ester; (2-Methoxy-5-(trifluoromethoxy)phenyl)boronic acid pinacol ester; 5-Methoxy-2-(trifluoromethoxy)phenylboronic acid pinacol ester; 2-Methoxy-5-trifluoromethoxyphenylboronic acid neopentyl glycol ester (common alternative); 2-Methoxy-α,α,α-trifluoro-p-cresylboronic acid pinacol ester; Boronic acid, B-[2-methoxy-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester; CAS 1688666-59-2
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-Trifluoromethoxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.