Description

4-Fluoro-2-Isopropoxyphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is a protected boronic acid derivative, offering enhanced stability for handling and storage compared to its free acid form, which is critical for complex multi-step synthesis. It serves as a key building block in cross-coupling reactions, such as the Suzuki-Miyaura reaction, for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex biaryl and heterobiaryl scaffolds common in modern drug discovery.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine and isopropoxy substituents can impart desirable biological activity and metabolic stability.
• Material Science Research: Employed in the creation of organic electronic materials, including monomers for conductive polymers, liquid crystals, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: The primary application is as a stable, air-handleable coupling partner with various organic halides or triflates to form new carbon-carbon bonds under palladium catalysis.
• Chemical Biology & Probe Development: Useful for synthesizing tagged molecules or bioconjugates used in diagnostic assays and molecular imaging.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.

Basic Information

Product Name	4-Fluoro-2-Isopropoxyphenylboronic Acid Pinacol Ester
CAS No.	1688656-87-2
Molecular Formula	C15H22BFO3
Molecular Weight	280.14 g/mol
Synonyms	4-Fluoro-2-isopropoxybenzeneboronic acid pinacol ester; 2-(4-Fluoro-2-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-Fluoro-2-isopropoxyphenyl)boronic acid pinacol ester; Pinacol (4-fluoro-2-isopropoxyphenyl)boronate; 4-Fluoro-2-isopropoxybenzeneboronic acid, pinacol ester; Boronic acid, B-(4-fluoro-2-isopropoxyphenyl)-, 1,1,1',1'-tetramethyl-2,2'-bi-1,3,2-dioxaborolane-4,4'-diyl ester; CAS 1688656-87-2
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Isopropoxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to consistent quality and traceability supports your R&D and scale-up processes with reliable, specification-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal purity and stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.