Description

[Met(O)14]-Exenatide (1 Mg) is a high-purity, synthetic peptide analog of exenatide featuring a specific methionine sulfoxide modification at position 14. This compound is critical for advanced pharmaceutical research and development, particularly in the study of peptide stability, oxidative stress mechanisms, and the development of next-generation therapeutic agents. It is primarily utilized by research institutions, biotechnology firms, and pharmaceutical companies engaged in metabolic disease research, drug discovery, and analytical method development.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material for the quality control and analytical validation of exenatide-based therapeutics and biosimilars.
• Metabolic Research: Used as a key tool in preclinical studies to investigate the role of oxidative post-translational modifications on GLP-1 receptor agonist activity and pharmacokinetics.
• Drug Discovery & Development: Employed in the design and screening of novel peptide therapeutics with enhanced stability profiles for treating type 2 diabetes and obesity.
• Analytical Method Development: Essential for developing and calibrating advanced analytical techniques such as LC-MS/MS and HPLC for peptide characterization and impurity profiling.
• Stability Studies: Acts as a specific marker or subject in studies examining the oxidation pathways and shelf-life stability of peptide drug products.
• Bioconjugation & Labeling Studies: Provides a modified peptide backbone for research into site-specific conjugation techniques for creating targeted drug delivery systems.

Basic Information

Product Name	[Met(O)14]-Exenatide (1 Mg)
CAS No.	1678417-38-3
Molecular Formula	C184H282N50O60S
Molecular Weight	4189.6 g/mol
Synonyms	Exenatide (Met(O)14); [Oxidized Methionine14]-Exenatide; Exendin-4 (1-39), 14-L-methionine sulfoxide; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met(O)-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2; AC2993 (Met(O)14); LY2148568 (modified)
EINECS	Contact for details

Quality Control

Our [Met(O)14]-Exenatide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications requiring the highest levels of accuracy and reproducibility.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by ESI-MS or MALDI-TOF
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.