Description

(D-His1)-Exenatide CAS NO 1678417-09-8 is a synthetic, stabilized analog of the glucagon-like peptide-1 (GLP-1) receptor agonist, engineered for enhanced metabolic stability and therapeutic potential. This high-purity peptide is critical for advanced pharmaceutical research and development, particularly in the study of diabetes and metabolic disorders. It serves as a key intermediate or reference standard for biopharmaceutical companies, academic research institutions, and contract development and manufacturing organizations (CDMOs) focused on next-generation peptide therapeutics.

Application

• Pharmaceutical R&D Intermediate: Serves as a critical building block in the synthesis of novel, long-acting GLP-1 receptor agonists for the treatment of Type 2 diabetes and obesity.
• Reference Standard: Used as a high-purity analytical standard in quality control (QC) and quality assurance (QA) laboratories for method development, validation, and batch release testing of related peptide APIs.
• Metabolic Research: A vital tool for in vitro and in vivo studies investigating GLP-1 receptor signaling, insulin secretion mechanisms, and β-cell function.
• Preclinical Development: Employed in pharmacokinetic, pharmacodynamic, and toxicology studies to evaluate the efficacy and safety profile of modified exenatide analogs.
• Process Chemistry: Used in the development and optimization of large-scale solid-phase or solution-phase peptide synthesis (SPPS) processes.

Basic Information

Item	Detail
Product Name	(D-His1)-Exenatide
CAS No.	1678417-09-8
Molecular Formula	C184H282N50O60S
Molecular Weight	4188.6 g/mol
Synonyms	Exenatide (D-His1) analog; [D-His1]-Exendin-4(1-39); [D-His1] Exenatide; (D-His1)-Exendin-4; L-His-D-histidyl-glycyl-L-glutamyl-L-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-glutamyl-L-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginyl-L-glycyl-L-glycyl-L-prolyl-L-seryl-L-seryl-glycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide; GLP-1 receptor agonist analog
EINECS	Contact for details

Quality Control

Our (D-His1)-Exenatide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided, reporting results for HPLC purity, related substances, peptide content, residual solvents, and endotoxins as applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 10.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.