Description

Biotinyl-(Glu1)-Orexin A (Human, Mouse, Rat) CAS NO 1678416-50-6 is a biotinylated analog of the neuropeptide Orexin A, designed for high-affinity detection and isolation in research applications. This modified peptide is critical for advancing neuroscience and metabolic research by enabling precise tracking and quantification of Orexin A receptor interactions. It is an essential reagent for pharmaceutical R&D, academic laboratories, and diagnostic developers focused on sleep-wake regulation, energy homeostasis, and neuroendocrine signaling pathways.

Application

• Neuroscience Research: Used as a labeled ligand in receptor binding assays, autoradiography, and fluorescence imaging to study the orexinergic system in the brain.
• Drug Discovery & Development: Serves as a key tool compound for screening and characterizing potential therapeutics targeting Orexin 1 (OX1) and Orexin 2 (OX2) receptors.
• Immunoassay Development: Employed in the development of sensitive ELISA and other immunoassay kits for the detection and quantification of Orexin A and its receptors.
• Pull-down & Affinity Purification: Utilizes the biotin tag for streptavidin-based isolation of Orexin A receptor complexes from cell lysates or tissue homogenates for proteomic analysis.
• Metabolic & Behavioral Studies: Applied in research models investigating the role of orexin in feeding behavior, addiction, arousal, and energy expenditure.
• Cell Signaling Pathway Analysis: Facilitates the study of downstream signaling cascades activated upon Orexin A receptor engagement.

Basic Information

Product Name	Biotinyl-(Glu1)-Orexin A (Human, Mouse, Rat)
CAS No.	1678416-50-6
Molecular Formula	C185H288N54O55S2
Molecular Weight	~4180.7 g/mol
Synonyms	Biotin-Orexin A; Biotinylated Orexin A; Biotin-OXA; Biotinyl-Orexin-A; Hypocretin-1 (1-33), Biotinyl-Glu1-; Biotinyl-Glutamyl-Orexin A; Biotinyl-(Glu1)-Hypocretin-1 (Human, Mouse, Rat); [Biotinyl-Glu1]-Orexin A
EINECS	Contact for details

Quality Control

Our Biotinyl-(Glu1)-Orexin A is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to rigorous analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and other critical specifications are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.