Description

(Des-Glu22)-Amyloid β-Protein (1-40) CAS NO 1678416-36-8 is a specifically modified peptide fragment of the amyloid beta protein, a key molecule in Alzheimer's disease research. This compound is crucial for studying the structure-activity relationship and aggregation behavior of amyloid beta, particularly the role of the glutamic acid residue at position 22. It is primarily used by academic researchers, pharmaceutical R&D teams, and diagnostic developers focused on neurodegenerative diseases and therapeutic target validation.

Application

• Biochemical Research: Fundamental studies on amyloid beta peptide aggregation kinetics, fibril formation, and toxicity mechanisms.
• Drug Discovery & Screening: Used as a target or tool compound in high-throughput assays to identify and evaluate potential inhibitors of amyloid aggregation.
• Antibody & Diagnostic Development: Serves as a critical antigen for characterizing the specificity of therapeutic antibodies or for developing immunoassays targeting modified amyloid beta species.
• Structure-Function Studies: Investigating the contribution of specific amino acid residues (like Glu22) to the peptide's secondary structure, stability, and pathogenic properties.
• In Vitro Model Systems: Used to create controlled cellular or acellular models of amyloid pathology for mechanistic studies.

Basic Information

Product Name	(Des-Glu22)-Amyloid β-Protein (1-40)
CAS No.	1678416-36-8
Molecular Formula	C194H295N55O57S
Molecular Weight	4329.8 g/mol
Synonyms	Aβ(1-40) (Des-Glu22); Amyloid β-Protein (1-40) (Des-Glu22); Des-Glu22-Aβ40; DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; Abeta40 (δE22); Aβ1-40 (δE22); Modified Amyloid β-Peptide (1-40); Amyloid-β (1-40) E22 deletion mutant
EINECS	Contact for details

Quality Control

Our (Des-Glu22)-Amyloid β-Protein (1-40) is produced and analyzed under stringent conditions to ensure high purity, correct sequence, and batch-to-batch consistency, which are critical for reproducible research outcomes. Each lot is characterized by advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption. Reconstituted solutions should be aliquoted and stored at ≤ -20°C; avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Molecular Weight	4329.8 ± 2 Da (MALDI-TOF MS)
Identification (MS)	Consistent with theoretical mass
Solubility	Soluble in water, DMSO, or dilute acetic acid
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.