Description

Amyloid β-Protein (1-40) S26C is a synthetic, site-specifically modified peptide fragment of the amyloid precursor protein, where the serine at position 26 is substituted with a cysteine residue. This engineered variant is crucial for advanced biochemical research, enabling site-directed labeling and cross-linking studies to elucidate the structure and aggregation mechanisms of amyloid beta. It is an essential research-grade reagent for scientists and institutions in the fields of neuroscience, biochemistry, and pharmaceutical development, particularly those investigating Alzheimer's disease pathology and therapeutic interventions.

Application

• Biochemical Research: Fundamental studies on the aggregation kinetics, oligomer formation, and structural properties of amyloid beta peptides.
• Drug Discovery & Screening: Used as a target substrate in high-throughput assays to identify and validate potential inhibitors of amyloid aggregation for Alzheimer's disease therapeutics.
• Structural Biology: Enables site-specific labeling with fluorescent dyes, spin labels, or other probes for techniques like FRET, NMR, and EPR spectroscopy to study conformational changes.
• Antibody & Diagnostic Development: Serves as a critical antigen for the production and characterization of antibodies specific to modified amyloid beta epitopes, aiding in diagnostic assay development.
• Toxicity Studies: Used in cellular and animal models to investigate the neurotoxic effects of specific amyloid beta variants and their role in disease progression.
• Biophysical Analysis: Key material for techniques such as surface plasmon resonance (SPR), isothermal titration calorimetry (ITC), and atomic force microscopy (AFM) to study protein-protein interactions.

Basic Information

Product Name	Amyloid β-Protein (1-40) S26C
CAS No.	1678415-32-1
Molecular Formula	C194H295N55O58S
Molecular Weight	4329.8 g/mol
Synonyms	Amyloid β-Protein (1-40) S26C; Aβ(1-40) S26C; Amyloid β-Peptide (1-40) (Human) S26C mutant; DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA S26C; β-Amyloid (1-40), S26C; CAS 1678415-32-1; Aβ40 S26C
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (1-40) S26C is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to rigorous quality testing protocols, including advanced chromatographic and mass spectrometric analyses, to guarantee product integrity. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into smaller quantities after first use to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Molecular Weight	4329.8 ± 2 Da (MALDI-TOF MS)
Solubility	Soluble in water, DMSO, or dilute acetic acid
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.