Description

5-Fam-Amylin (Mouse, Rat) is a fluorescently labeled analog of the pancreatic hormone amylin, specifically designed for research applications involving rodent models. This compound is a critical tool for studying amylin's role in glucose metabolism, satiety signaling, and its aggregation behavior in diabetes research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on metabolic disorders, peptide biochemistry, and fluorescence-based assay development.

Application

• Fluorescence Resonance Energy Transfer (FRET) Studies: Used as a donor or acceptor probe to investigate protein-protein interactions involving amylin.
• Cellular Uptake and Localization: Visualization and tracking of amylin internalization and trafficking in live or fixed rodent-derived cells.
• Binding Assays: Employed in competitive binding studies to quantify affinity for the amylin receptor (AMY receptor) or other targets.
• Aggregation Kinetics Monitoring: Real-time fluorescence measurement of amylin fibril formation and amyloid aggregation, relevant to type 2 diabetes pathology.
• In Vivo Imaging: Aids in pharmacokinetic and biodistribution studies in mouse and rat models when compatible with imaging modalities.
• Peptide Stability and Degradation Studies: Acts as a tracer to monitor the stability of amylin under various experimental conditions.

Basic Information

Product Name	5-Fam-Amylin (Mouse, Rat)
CAS No.	1678415-03-6
Molecular Formula	C178H267N51O53S2
Molecular Weight	3903.5 g/mol (approximate)
Synonyms	FAM-Amylin (rodent); 5-Carboxyfluorescein-Amylin (mouse, rat); Fluorescein-labeled Amylin; FAM-Islet Amyloid Polypeptide (IAPP); 5-FAM-IAPP(1-37) (mouse, rat); 5-FAM-Cys2-IAPP; Fluorescent Amylin Tracer; 5-FAM-hIAPP (rodent sequence)
EINECS	Contact for details

Quality Control

Our 5-Fam-Amylin (Mouse, Rat) is manufactured under strict quality protocols suitable for research use. Each batch is characterized to ensure identity, purity, and performance consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC purity analysis, mass spectrometry (MS) confirmation, and fluorescence intensity verification. We adhere to a quality management system to guarantee reliable and reproducible material for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider aliquoting to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Yellow to orange lyophilized solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Fluorophore Incorporation	≥ 0.9 mol FAM / mol peptide
Solubility	Soluble in DMSO, DMF; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.