Description

3-Chloro-4-Ethoxy-5-Fluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for modern cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

This versatile boronic ester is a key intermediate in advanced organic synthesis, with primary applications including:

• Pharmaceutical Intermediates: A critical building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Development: Used to construct complex heterocyclic cores found in next-generation herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology Probes: Serves as a precursor for labeling reagents and probe molecules used in bio-conjugation and target identification studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for the production of bespoke compounds and advanced intermediates.

Basic Information

Product Name	3-Chloro-4-Ethoxy-5-Fluorophenylboronic Acid Pinacol Ester
CAS No.	1668474-08-5
Molecular Formula	C14H19BClFO3
Molecular Weight	300.56 g/mol
Synonyms	3-Chloro-4-ethoxy-5-fluorobenzeneboronic acid pinacol ester; 2-(3-Chloro-4-ethoxy-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3-Chloro-4-ethoxy-5-fluorophenyl)boronic acid pinacol ester; 3-Chloro-4-ethoxy-5-fluorophenyl-Bpin; B-(3-Chloro-4-ethoxy-5-fluorophenyl)boronic acid pinacol ester; CAS 1668474-08-5
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-4-Ethoxy-5-Fluorophenylboronic Acid Pinacol Ester adheres to stringent quality management protocols. Every batch is characterized and tested using advanced analytical techniques including NMR, HPLC, and GC to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.