Description

2-Hydroxy-3-(Diphenylphosphino)-2’-[Hydroxy[2-(Triethylsilyl)Phenyl]Methyl]-[1,1’-Binaphthalene] is a sophisticated, chiral organophosphorus ligand designed for advanced catalytic applications. This compound matters because it provides exceptional stereoselectivity and tunability in asymmetric synthesis, a critical requirement for producing high-value enantiopure pharmaceuticals and fine chemicals. Industrial researchers and process chemists in pharmaceutical development, agrochemical synthesis, and specialty chemical manufacturing need this ligand to achieve superior reaction efficiency and product purity. Its unique binaphthyl backbone, functionalized with phosphino and silyl-protected hydroxy groups, offers a versatile platform for constructing complex molecular architectures.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for rhodium, ruthenium, or iridium complexes used in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Enables the production of chiral active pharmaceutical ingredients (APIs) for cardiovascular, central nervous system, and oncological drugs.
• Asymmetric C-C Bond Formation: Facilitates critical reactions such as Suzuki-Miyaura cross-coupling, Heck reactions, and allylic alkylations with high enantiomeric excess.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a precursor or chiral inducer in the development of advanced polymers and liquid crystals with specific optical properties.
• Academic & Process R&D: A valuable tool for methodology development in university laboratories and industrial R&D centers exploring new catalytic cycles.

Basic Information

Product Name	2-Hydroxy-3-(Diphenylphosphino)-2’-[Hydroxy[2-(Triethylsilyl)Phenyl]Methyl]-[1,1’-Binaphthalene]
CAS No.	1661883-81-3
Molecular Formula	C51H51O2PSi
Molecular Weight	755.00 g/mol
Synonyms	(R)- or (S)-2-Hydroxy-3-(diphenylphosphino)-2'-[hydroxy(2-(triethylsilyl)phenyl)methyl]-1,1'-binaphthalene; BINOL-Derived Phosphine Ligand; Chiral Binaphthyl Phosphine Ligand; Si-Protected Hydroxy-Functionalized BINAP Analog; Triethylsilyl-BINOL-Phosphine Hybrid Ligand; DESPHOS Derivative; Asymmetric Hydrogenation Ligand 1661883-81-3
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure consistency and performance in sensitive catalytic applications. Standard quality parameters include chiral purity (enantiomeric excess) verified by chiral HPLC, chemical purity assessed by NMR and elemental analysis, and confirmation of structure by spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all test results. Our manufacturing aligns with cGMP principles where required, supporting our commitment to supply reliability for critical pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). The compound is easily oxidized and light-sensitive; therefore, containers should be kept sealed and only opened in a dry, inert glovebox or under a positive pressure of inert gas to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (specify R or S)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.