Description

2’-[2-Biphenylyl(Hydroxy)Methyl]-2-Hydroxy-3-(Diphenylphosphino)-[1,1’-Binaphthalene] is a sophisticated, chiral phosphine-oxazoline hybrid ligand, a key component in asymmetric catalysis. This compound matters for its ability to impart high enantioselectivity and catalytic efficiency in critical carbon-carbon and carbon-heteroatom bond-forming reactions. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for synthesizing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amino acids and pharmaceutical intermediates.
• As a key catalyst component in asymmetric allylic substitution reactions to construct chiral carbon centers.
• For enantioselective C-C cross-coupling reactions, including Suzuki-Miyaura and Heck reactions, in fine chemical synthesis.
• In the asymmetric synthesis of natural products and complex molecules requiring high optical purity.
• As a research chemical for developing novel catalytic systems and methodologies in academic and industrial laboratories.
• For process development and scale-up of chiral APIs under Current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	2’-[2-Biphenylyl(Hydroxy)Methyl]-2-Hydroxy-3-(Diphenylphosphino)-[1,1’-Binaphthalene]
CAS No.	1661883-77-7
Molecular Formula	C51H39O2P
Molecular Weight	714.83 g/mol
Synonyms	(S)-2'-[2-Biphenylyl(hydroxy)methyl]-2-hydroxy-3-(diphenylphosphino)-1,1'-binaphthalene; (S)-Biphenyl-PHOX Ligand; Biphenyl-PHOX; Chiral Biphenyl Phosphino-Oxazoline Ligand; (S)-2'-(α-Hydroxy-2-biphenylylmethyl)-2-diphenylphosphino-1,1'-binaphthyl-3-ol; PHOX-type Ligand; Asymmetric Hydrogenation Ligand; CAS 1661883-77-7
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested to meet the stringent requirements of advanced synthetic chemistry. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and identity confirmation. Our quality systems ensure traceability and consistency, supporting development from laboratory research to commercial-scale manufacturing under ISO-certified quality management.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, cool place. This compound is hygroscopic and sensitive to oxidation; prolonged exposure to air or moisture should be avoided to maintain purity and catalytic activity.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.