Description

2'-[(1,1-Dimethylethyl)Phenylphosphino]-N2,N2,N6,N6-Tetramethyl-[1,1'-Biphenyl]-2,6-Diamine is a sophisticated, high-value organophosphorus ligand with a sterically demanding, electron-rich structure. Its primary value lies in its exceptional ability to modulate the activity and selectivity of transition metal catalysts, particularly in cross-coupling and hydrogenation reactions. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise control over asymmetric synthesis and challenging bond-forming transformations.

Application

• Pharmaceutical Intermediate Synthesis: As a key ligand for palladium and nickel catalysts in the synthesis of complex, chiral drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Catalysis: Enabling highly enantioselective hydrogenation and C-C bond coupling reactions critical for producing single-isomer compounds.
• Agrochemical Research: Facilitating the development of novel, more effective herbicides and pesticides through tailored catalytic processes.
• Polymer & Material Science: Used in catalyst systems for the polymerization of specialty monomers to create polymers with unique thermal or mechanical properties.
• Academic & Industrial R&D: A valuable tool for exploring new catalytic methodologies and reaction pathways in both university and corporate research laboratories.
• Fine Chemical Manufacturing: Improving yield and selectivity in the multi-step synthesis of high-value, complex organic molecules.

Basic Information

Product Name	2'-[(1,1-Dimethylethyl)Phenylphosphino]-N2,N2,N6,N6-Tetramethyl-[1,1'-Biphenyl]-2,6-Diamine
CAS No.	1660153-91-2
Molecular Formula	C29H39N2P
Molecular Weight	446.60 g/mol
Synonyms	2'-(tert-Butylphenylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamine; t-BuPhos Ligand; 2'-[(tert-Butyl)Phenylphosphino]-N,N,N',N'-Tetramethylbiphenyl-2,6-diamine; JohnPhos-type Diamine Ligand; Biphenyl-based Phosphine-Diamine Ligand; (2'-(tert-Butylphenylphosphino)-N,N,N',N'-tetramethyl-[1,1'-biphenyl]-2,6-diamine); CAS 1660153-91-2
EINECS	Contact for details

Quality Control

Every batch of 2'-[(1,1-Dimethylethyl)Phenylphosphino]-N2,N2,N6,N6-Tetramethyl-[1,1'-Biphenyl]-2,6-Diamine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure high purity and batch-to-batch consistency, critical for reproducible catalytic performance. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profiles are available for every shipment. Our quality commitment supports applications in GMP-intermediate synthesis and other regulated environments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and light-sensitive; prolonged exposure to air or ambient light should be avoided. The container should be kept in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.