Description

4-Acetylsulfanilamide-13C6 is a stable isotope-labeled analog of the sulfonamide antibiotic precursor, 4-acetylsulfanilamide, where six carbon atoms are replaced with the carbon-13 isotope. This compound is essential for use as an internal standard in quantitative mass spectrometry, providing unmatched accuracy and reliability for pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in the development and quality control of sulfonamide-based drugs.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise LC-MS/MS quantification of sulfanilamide and related metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracing of drug absorption, distribution, metabolism, and excretion (ADME) profiles for sulfonamide drug candidates.
• Pharmaceutical Impurity Profiling: Used in method development to detect and quantify process-related impurities and degradation products in active pharmaceutical ingredients (APIs).
• Clinical Research: Supports therapeutic drug monitoring (TDM) and clinical trial sample analysis to ensure patient safety and efficacy data integrity.
• Veterinary Drug Residue Testing: Applied in food safety testing to monitor sulfonamide antibiotic residues in animal-derived products.
• Environmental Analysis: Facilitates the sensitive detection and quantification of sulfonamide pollutants in water and soil samples.

Basic Information

Product Name	4-Acetylsulfanilamide-13C6
CAS No.	1655498-04-6
Molecular Formula	C213C6H12N2O3S
Molecular Weight	~222.2 g/mol (labeled)
Synonyms	N-(4-Aminophenyl)sulfonylacetamide-13C6; Sulfanilamide N4-acetate-13C6; 4-Acetamidobenzenesulfonamide-13C6; 4-Acetylsulfanilamide (13C6); N1-Acetylsulfanilamide-13C6; p-Acetylsulfanilamide-13C6; A13C6SA; [13C6]-4-Acetylsulfanilamide
EINECS	Contact for details

Quality Control

Every batch of 4-Acetylsulfanilamide-13C6 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment to meet the exacting demands of analytical reference standards. Comprehensive testing includes identity confirmation, assay by HPLC, and verification of isotopic purity by mass spectrometry. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % 13C
Isotopic Enrichment	≥ 99% on six labeled positions
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.