Description

Fmoc-n-Amido-Peg1-Acid CAS NO 1654740-73-4 is a specialized, high-purity building block used in solid-phase peptide synthesis (SPPS). This compound is critical for introducing a polyethylene glycol (PEG) spacer with a terminal carboxylic acid group, which is essential for modifying peptides to improve their solubility, stability, and pharmacokinetic properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, diagnostics, and bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the controlled assembly of complex peptides.
• Peptide Modification and Conjugation: Introducing hydrophilic PEG linkers to enhance peptide solubility and reduce immunogenicity.
• Bioconjugation and Linker Chemistry: Serving as a versatile spacer for attaching peptides to other molecules, surfaces, or nanoparticles.
• Drug Discovery & Development: A crucial reagent in the research and development of novel peptide drugs and targeted therapies.
• Antibody-Drug Conjugate (ADC) Research: Used in the synthesis of peptide linkers for connecting cytotoxic payloads to antibodies.
• Chemical Biology Probes: For creating labeled peptides used in cellular imaging and mechanism-of-action studies.

Basic Information

Product Name	Fmoc-n-Amido-Peg1-Acid
CAS No.	1654740-73-4
Molecular Formula	C₂₂H₂₃NO₆
Molecular Weight	397.42 g/mol
Synonyms	Fmoc-8-amino-3,6-dioxaoctanoic acid; Fmoc-NH-PEG1-COOH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-8-amino-3,6-dioxaoctanoic acid; 2-{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid; Fmoc-Ado(PEG1)-OH; Fmoc-AEEA-OH; Fmoc-N-amido-PEG1-acid; 8-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3,6-dioxaoctanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-n-Amido-Peg1-Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥95% (HPLC). Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.