Description

Fmoc-Phe-Lys(Boc)-Pab-Pnp CAS NO 1646299-50-4 is a specialized, protected tetrapeptide building block designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptide sequences with precise control. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories engaged in developing novel therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected intermediate for the sequential assembly of custom peptide chains.
• Pharmaceutical Research: For the development and scale-up of novel peptide-based drug candidates, including targeted therapies.
• Bioconjugation: The Pnp (p-nitrophenyl ester) active ester group facilitates efficient coupling to amines, useful for creating peptide-protein or peptide-polymer conjugates.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify bioactive peptide leads.
• Protease Substrate Synthesis: Employed in constructing specific peptide sequences to study enzyme kinetics and inhibition.
• Antibody-Drug Conjugate (ADC) Linker Exploration: The structure can serve as a model for designing cleavable linkers in targeted drug delivery systems.

Basic Information

Product Name	Fmoc-Phe-Lys(Boc)-Pab-Pnp
CAS No.	1646299-50-4
Molecular Formula	C₅₀H₆₁N₇O₁₁
Molecular Weight	936.07 g/mol
Synonyms	Fmoc-Phe-Lys(Boc)-Pab-OPnp; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl-4-(aminomethyl)benzoic acid 4-nitrophenyl ester; Fmoc-Phe-Lys(Boc)-PAB(Opnp); Fmoc-Phenylalanyl-Nε-Boc-lysyl-PAB-p-nitrophenyl ester; Fmoc-F-K(Boc)-Pab-OPnp; Tetrapeptide SPPS Intermediate 1646299-50-4; Protected Peptide Building Block
EINECS	Contact for details

Quality Control

Our Fmoc-Phe-Lys(Boc)-Pab-Pnp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for advanced peptide synthesis. Certificates of Analysis (COA) providing detailed HPLC purity, chiral integrity, and spectroscopic identification data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.