Description

tert-Butyl 3-(2-Aminopropan-2-yl)azetidine-1-carboxylate is a high-purity, protected azetidine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile, reactive amine handle for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within therapeutic areas requiring nitrogen-rich heterocycles.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Medicinal Chemistry Scaffold: Used to introduce the azetidine moiety, a valuable bioisostere for ring-constrained amine functionalities that can improve potency, selectivity, and metabolic stability.
• Process Chemistry & Scale-Up: Serves as a reliable starting material for the development and optimization of scalable synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Research: Employed in the discovery and synthesis of new crop protection agents and herbicides that require specific amine functionalities.
• Ligand & Catalyst Development: Utilized for constructing sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Acts as a building block for creating molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	tert-Butyl 3-(2-Aminopropan-2-yl)azetidine-1-carboxylate
CAS No.	1638768-77-0
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-Boc-3-(2-aminopropan-2-yl)azetidine; tert-Butyl 3-(2-amino-2-propyl)azetidine-1-carboxylate; 3-(2-Amino-2-propyl)azetidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-(2-aminopropan-2-yl)azetidine; Boc-3-(2-aminopropan-2-yl)azetidine; Azetidine-1-carboxylic acid, 3-(2-amino-2-propyl)-, 1,1-dimethylethyl ester; 1638768-77-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(2-Aminopropan-2-yl)azetidine-1-carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to support regulatory filings, and we can supply material that aligns with ICH guidelines for impurities (Q3A, Q3B) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.