Description

2-(1,1-Difluoroethyl)-Benzenemethanamine is a specialized fluorinated aromatic amine building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the difluoroethyl group, enabling the development of novel molecular architectures. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for creating new active ingredients, particularly in medicinal chemistry for lead optimization and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in areas targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity, stability, and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of advanced polymers, liquid crystals, or specialty coatings with tailored properties.
• Chemical Biology Probe Synthesis: Employed to create labeled compounds or molecular probes for studying biological pathways and protein interactions.
• Catalyst and Ligand Development: Utilized as a starting material for constructing novel chiral or non-chiral ligands used in asymmetric catalysis and transition metal complexes.
• Fluorine Chemistry Research: A valuable substrate for studying the introduction and transformation of fluorinated functional groups in organic molecules.

Basic Information

Product Name	2-(1,1-Difluoroethyl)-Benzenemethanamine
CAS No.	1638767-86-8
Molecular Formula	C9H11F2N
Molecular Weight	171.19 g/mol
Synonyms	α-(1,1-Difluoroethyl)benzylamine; 1-(1,1-Difluoroethyl)-1-phenylmethanamine; Benzenemethanamine, 2-(1,1-difluoroethyl)-; (1,1-Difluoroethyl)phenylmethylamine; 2-(1,1-Difluoroethyl)benzylamine; [2-(1,1-Difluoroethyl)phenyl]methanamine; 1-Phenyl-2,2-difluoropropan-1-amine
EINECS	Contact for details

Quality Control

Every batch of 2-(1,1-Difluoroethyl)-Benzenemethanamine is produced and analyzed under strict quality management protocols to ensure consistency and purity for research and development applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.