Description

cis-3-Aminocyclobutanecarbonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique strained cyclobutane scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates targeting a range of therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained cyclobutane ring.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component or a functionalized moiety in bifunctional molecule design.
• Agrochemical Synthesis: Intermediate in the development of new active ingredients with potential insecticidal or herbicidal properties.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function and biological pathways.
• Academic Research: Employed in organic synthesis methodology development and the exploration of new chemical space.

Basic Information

Product Name	cis-3-Aminocyclobutanecarbonitrile Hydrochloride
CAS No.	1638765-32-8
Molecular Formula	C5H9N2•HCl
Molecular Weight	132.60 g/mol
Synonyms	3-Aminocyclobutanecarbonitrile hydrochloride, cis-; Cyclobutanecarbonitrile, 3-amino-, hydrochloride, cis-; (1r,3s)-3-Aminocyclobutanecarbonitrile hydrochloride; (1s,3r)-3-Aminocyclobutanecarbonitrile hydrochloride; cis-3-Amino-cyclobutanecarbonitrile HCl; 3-Amino-cis-cyclobutanecarbonitrile hydrochloride; cis-3-Cyano-cyclobutanamine hydrochloride
EINECS	Contact for details

Quality Control

Our cis-3-Aminocyclobutanecarbonitrile Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.