Description

trans-3-Aminocyclobutanecarbonitrile Hydrochloride is a high-purity, pharmaceutically relevant building block used in the synthesis of novel active compounds. This cyclobutane derivative is valued for its rigid, three-dimensional structure, which is crucial for modulating the biological activity and physicochemical properties of drug candidates. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for research and development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry: Used to introduce the constrained cyclobutane scaffold into molecules to explore structure-activity relationships (SAR) and improve potency, selectivity, and metabolic stability.
• Peptidomimetics: Serves as a non-natural amino acid analog for the design of novel peptide-like compounds with enhanced pharmacological profiles.
• Chemical Biology: Employed as a tool compound or a building block for the synthesis of chemical probes to study biological pathways and protein function.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for advanced pharmaceutical intermediates (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Agrochemical Research: Potential application as an intermediate in the discovery of new crop protection agents with novel modes of action.

Basic Information

Product Name	trans-3-Aminocyclobutanecarbonitrile Hydrochloride
CAS No.	1638764-93-8
Molecular Formula	C5H9N2•HCl
Molecular Weight	132.60 g/mol (Free base: 96.14 g/mol)
Synonyms	trans-3-Aminocyclobutanecarbonitrile HCl; (1r,3r)-3-Aminocyclobutanecarbonitrile Hydrochloride; (1s,3s)-3-Aminocyclobutanecarbonitrile Hydrochloride; trans-3-Amino-1-cyanocyclobutane Hydrochloride; 3-Aminocyclobutanecarbonitrile Hydrochloride (trans-); Cyclobutanecarbonitrile, 3-amino-, hydrochloride, trans-; 1-Cyano-3-aminocyclobutane Hydrochloride (trans-); 3-Aminocyclobutanenitrile Hydrochloride (trans-)
EINECS	Contact for details

Quality Control

Our trans-3-Aminocyclobutanecarbonitrile Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant quality management standards to ensure supply reliability and product integrity for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.