Description

tert-Butyl n-[3-(Hydroxycarbamoyl)Cyclobutyl]Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a cyclobutyl core functionalized with both a carbamate and a hydroxamic acid derivative. This compound is valued for its role as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents. It is primarily sought by research and development teams in the pharmaceutical and biotechnology sectors for the development of new drug candidates, particularly in areas requiring complex, constrained molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs), particularly for small molecule drugs.
• Protease Inhibitor Synthesis: Serves as a crucial scaffold in the design and synthesis of protease inhibitors, a major class of therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of novel compounds.
• Bioconjugation & Probe Development: The reactive hydroxamic acid group makes it suitable for creating chemical probes or bioconjugates for biochemical research.
• Chemical Biology Tool: Employed in the development of chemical tools to study enzyme function and cellular pathways.
• Custom Synthesis Building Block: Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.

Basic Information

Product Name	tert-Butyl n-[3-(Hydroxycarbamoyl)Cyclobutyl]Carbamate
CAS No.	1638761-12-2
Molecular Formula	C10H18N2O4
Molecular Weight	230.26 g/mol
Synonyms	tert-Butyl (3-(hydroxycarbamoyl)cyclobutyl)carbamate; N-Boc-3-(hydroxycarbamoyl)cyclobutanamine; 3-((tert-Butoxycarbonyl)amino)cyclobutane-1-carbohydroxamic acid; 1-N-Boc-3-aminocyclobutanecarbohydroxamic acid; Cyclobutanamine, 3-(hydroxycarbamoyl)-, N-Boc derivative; BOC-3-Aminocyclobutanecarbohydroxamic Acid; tert-Butyl 3-(hydroxycarbamoyl)cyclobutylcarbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[3-(Hydroxycarbamoyl)Cyclobutyl]Carbamate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.