Description

2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Phenol is a high-value boronic ester derivative, a critical intermediate in modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing drug candidates, especially those containing trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the boronate group for precise molecular assembly.
• Material Science: Serves as a precursor for functional polymers and organic electronic materials, where the phenol and boronate functionalities allow for further modification.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating complex organic molecules.
• Ligand Synthesis: Can be utilized to develop novel ligands for catalysis, taking advantage of the phenolic oxygen and the boronate moiety.

Basic Information

Product Name	2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Phenol
CAS No.	1638624-76-6
Molecular Formula	C13H16BF3O3
Molecular Weight	288.07 g/mol
Synonyms	5-(Trifluoromethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 2-Hydroxy-4-(trifluoromethyl)phenylboronic acid pinacol ester; [5-(Trifluoromethyl)-2-hydroxyphenyl]boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenol; 5-Trifluoromethyl-2-boronic acid pinacol ester phenol; CAS 1638624-76-6
EINECS	Contact for details

Quality Control

Our 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance for critical coupling reactions. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.