Description

Fmoc-Dl-Ala(Tbu)-Oh is a protected amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). Its value lies in the orthogonal protection strategy it provides, where the Fmoc group offers base-labile protection for the α-amino group, and the tert-butyl (Tbu) group provides acid-labile protection for the carboxylic acid side chain. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of novel peptides, APIs, and therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental monomer for the automated, stepwise construction of complex peptide chains using Fmoc-chemistry protocols.
• Pharmaceutical Intermediate: Serves as a key raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Probe Development: Used to incorporate alanine residues with protected side chains into peptides designed for labeling, imaging, or diagnostic applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Industrial Research: A standard reagent in laboratories focused on peptide science, structural biology, and medicinal chemistry.
• Custom Peptide Service Providers: A staple inventory item for companies offering bespoke peptide synthesis services to the research community.

Basic Information

Product Name	Fmoc-Dl-Ala(Tbu)-Oh
CAS No.	1637650-31-7
Molecular Formula	C₂₂H₂₅NO₅
Molecular Weight	383.44 g/mol
Synonyms	Fmoc-DL-3-Amino-2-(tert-butoxy)-2-oxopropanoic Acid; N-(9-Fluorenylmethoxycarbonyl)-3-amino-2-(tert-butoxy)-2-oxopropanoic Acid; Fmoc-DL-β-Amino-tert-butyloxycarbonylalanine; Fmoc-DL-Ala(OC(O)tBu)-OH; Fmoc-DL-3-Amino-2-(tert-butoxycarbonyl)propanoic Acid; Nα-Fmoc-DL-β-tert-Butyl aspartate; DL-Fmoc-Asp(OtBu)-OH (common misassignment for Ala(Tbu)); Fmoc-DL-2-Amino-3-(tert-butoxy)-3-oxopropanoic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-Dl-Ala(Tbu)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP manufacturing. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.