Description

Potassium (2,4-Difluorobenzyl)Trifluoroborate is an organotrifluoroborate salt, a highly valuable and stable synthetic intermediate in modern organic chemistry. Its primary value lies in its exceptional utility in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is particularly sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing difluorobenzyl motifs, which are prevalent in drug discovery for metabolic diseases and CNS disorders.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the introduction of fluorine atoms enhances biological activity and environmental stability.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs and charge-transport molecules, due to the electronic properties imparted by the fluorine substituents.
• Cross-Coupling Reactions: A reliable and air-stable boronic acid surrogate in palladium-catalyzed Suzuki-Miyaura couplings, offering advantages in handling and shelf-life over traditional boronic acids.
• Chemical Library Development: Essential for medicinal chemistry and high-throughput screening programs aimed at creating diverse compound libraries for biological evaluation.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	Potassium (2,4-Difluorobenzyl)Trifluoroborate
CAS No.	1632070-90-6
Molecular Formula	C7H5BF5K
Molecular Weight	234.02 g/mol
Synonyms	Potassium (2,4-Difluorophenyl)methyltrifluoroborate; (2,4-Difluorobenzyl)trifluoroborate Potassium Salt; Potassium (2,4-Difluorobenzyl)trifluoroboronate; 2,4-Difluorobenzyltrifluoroboronic Acid Potassium Salt; Potassium Trifluoro(2,4-difluorobenzyl)borate; (2,4-Difluorobenzyl)BF3K; K-2,4-Difluorobenzyl-BF3
EINECS	Contact for details

Quality Control

Our Potassium (2,4-Difluorobenzyl)Trifluoroborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 11B, 19F), HPLC, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality documentation to meet specific regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) when not in use to prevent moisture absorption and decomposition. Keep away from incompatible materials such as strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
11B NMR Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Potassium Content	15.0% - 18.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.