Description

n-[(8α,9S)-10,11-Dihydro-6'-Methoxycinchonan-9-Yl]-2-(Diphenylphosphino)-Benzamide is a sophisticated chiral ligand and organocatalyst derived from the cinchona alkaloid scaffold, modified with a phosphine group. This compound matters for its ability to impart high enantioselectivity in asymmetric synthesis, a critical factor for producing optically pure pharmaceuticals and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as asymmetric hydrogenation and carbon-carbon bond formation.

Application

• Asymmetric Catalysis: Employed as a chiral ligand in transition metal-catalyzed reactions, including asymmetric hydrogenation of olefins and ketones.
• Pharmaceutical Intermediate Synthesis: Used in the enantioselective synthesis of active pharmaceutical ingredients (APIs) and key chiral intermediates.
• Agrochemical Production: Facilitates the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for method development and exploring new asymmetric transformations in research laboratories.
• Fine Chemical Manufacturing: Applied in the production of high-value, optically active flavors, fragrances, and electronic chemicals.
• Ligand Library Development: Serves as a component in screening libraries for discovering new catalytic systems.

Basic Information

Product Name	n-[(8α,9S)-10,11-Dihydro-6'-Methoxycinchonan-9-Yl]-2-(Diphenylphosphino)-Benzamide
CAS No.	1630973-06-6
Molecular Formula	C39H37N3O2P
Molecular Weight	610.70 g/mol
Synonyms	(8α,9S)-10,11-Dihydro-6'-methoxycinchonan-9-yl 2-(diphenylphosphino)benzamide; 2-(Diphenylphosphino)-N-[(8α,9S)-10,11-dihydro-6'-methoxycinchonan-9-yl]benzamide; Cinchona Alkaloid-Derived Phosphine Ligand; Dihydrocinchonidine-Based Phosphine Ligand; Asymmetric Hydrogenation Ligand; Chiral Diphosphine Analogue; (S)-DHCD-Phos Benzamide
EINECS	Contact for details

Quality Control

Our production of n-[(8α,9S)-10,11-Dihydro-6'-Methoxycinchonan-9-Yl]-2-(Diphenylphosphino)-Benzamide adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for catalytic performance. All materials are characterized by advanced analytical techniques including NMR, HPLC, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be purged with inert gas before resealing after each use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.