Description

2',3',5'-Tri-o-Acetyl-5-Cyanouridine is a key nucleoside derivative and a crucial synthetic intermediate in the production of modified RNA and DNA analogs. This compound matters because it provides a protected and activated form of uridine, enabling precise chemical modifications for advanced oligonucleotide synthesis. Pharmaceutical researchers and fine chemical manufacturers need it for developing therapeutic nucleic acids, including antisense oligonucleotides and siRNA, as well as for creating diagnostic probes and research tools in molecular biology.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the solid-phase and solution-phase synthesis of modified RNA and DNA strands for therapeutic and research applications.
• Prodrug Development: Serves as a precursor in the design of prodrugs to enhance the bioavailability and targeting of nucleoside-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in studies investigating RNA structure, function, and metabolism, as well as in enzyme inhibition assays.
• Diagnostic Probe Manufacturing: Utilized to create labeled nucleic acid probes for techniques like FISH (Fluorescence In Situ Hybridization) and PCR.
• Academic & Contract Research: Supplied to universities and CROs (Contract Research Organizations) for discovery chemistry and medicinal chemistry programs.

Basic Information

Item	Detail
Product Name	2',3',5'-Tri-o-Acetyl-5-Cyanouridine
CAS No.	1630743-99-5
Molecular Formula	C16H17N3O9
Molecular Weight	395.32 g/mol
Synonyms	5-Cyano-2',3',5'-tri-O-acetyluridine; 5-Cyanouridine 2',3',5'-triacetate; 2',3',5'-Tri-O-acetyl-5-cyanouridine; 5-CN-2',3',5'-tri-O-Ac-Urd; Uridine, 5-cyano-, 2',3',5'-triacetate; 5-Cyano-2',3',5'-tri-O-acetyl-1-β-D-ribofuranosyluracil; 1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-5-cyanouracil
EINECS	Contact for details

Quality Control

Every batch of 2',3',5'-Tri-o-Acetyl-5-Cyanouridine is manufactured under a strict quality management system and undergoes comprehensive analytical testing. Our standard pharmaceutical intermediate grade ensures high purity and consistency for critical synthesis applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles via HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.