Description

Methyl2-Acetamido-3-(2,3,6-Trifluorophenyl)Propanoate CAS NO 1630096-65-9 is a high-purity fluorinated amino acid derivative, specifically a protected phenylalanine analog, designed for advanced pharmaceutical synthesis. This compound is a critical building block in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas where fluorination enhances metabolic stability and bioavailability. It is essential for medicinal chemistry research, process development, and scale-up manufacturing within the pharmaceutical and biotechnology sectors, offering a reliable and well-characterized starting material for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptide analogs and small molecule drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to incorporate fluorine atoms for improved drug-like properties.
• API Process Development: Serves as a critical raw material in the pilot and commercial-scale manufacturing of fluorinated active pharmaceutical ingredients.
• Protease Inhibitor Synthesis: A potential precursor in the development of inhibitors targeting specific enzymes.
• Peptidomimetic Construction: Employed to build non-natural amino acid residues into peptide backbones to enhance stability and potency.
• Chemical Biology Probes: Utilized in the creation of fluorinated probes for studying biological mechanisms and target engagement.

Basic Information

Product Name	Methyl2-Acetamido-3-(2,3,6-Trifluorophenyl)Propanoate
CAS No.	1630096-65-9
Molecular Formula	C12H11F3NO3
Molecular Weight	274.22 g/mol
Synonyms	Methyl N-acetyl-3-(2,3,6-trifluorophenyl)-L-alaninate; (2S)-2-Acetamido-3-(2,3,6-trifluorophenyl)propanoic acid methyl ester; N-Acetyl-2,3,6-trifluoro-L-phenylalanine methyl ester; Methyl (2S)-2-acetamido-3-(2,3,6-trifluorophenyl)propanoate; L-Phenylalanine, N-acetyl-2,3,6-trifluoro-, methyl ester; 1630096-65-9; Methyl N-acetyl-2,3,6-trifluoro-L-phenylalaninate
EINECS	Contact for details

Quality Control

Our Methyl2-Acetamido-3-(2,3,6-Trifluorophenyl)Propanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.