Description

[2-(Hydroxymethyl)-4-(Trifluoromethyl)Phenyl]Boronic Acid is a high-value, multifunctional boronic acid derivative essential for modern synthetic chemistry. Its core value lies in serving as a versatile building block for constructing complex molecules via the powerful Suzuki-Miyaura cross-coupling reaction. This compound is critically needed by R&D and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles by introducing the trifluoromethylphenyl moiety.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysts used in asymmetric synthesis and other advanced catalytic processes.
• Functional Material Precursor: Integral in synthesizing organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its ability to form conjugated systems.
• Chemical Biology & Proteomics: Serves as a handle for bioconjugation and the development of activity-based probes and sensors leveraging boronic acid-diol interactions.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client R&D pipelines.

Basic Information

Product Name	[2-(Hydroxymethyl)-4-(Trifluoromethyl)Phenyl]Boronic Acid
CAS No.	1629148-48-6
Molecular Formula	C8H8BF3O3
Molecular Weight	219.96 g/mol
Synonyms	(2-(Hydroxymethyl)-4-(trifluoromethyl)phenyl)boronic acid; 2-(Hydroxymethyl)-4-(trifluoromethyl)benzeneboronic acid; [2-(Hydroxymethyl)-4-(trifluoromethyl)phenyl]boronic acid; Boronic acid, B-[2-(hydroxymethyl)-4-(trifluoromethyl)phenyl]-; 4-(Trifluoromethyl)-2-(hydroxymethyl)phenylboronic acid; 2-Hydroxymethyl-4-trifluoromethylphenylboronic acid
EINECS	Contact for details

Quality Control

Our [2-(Hydroxymethyl)-4-(Trifluoromethyl)Phenyl]Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.