Description

4-Cyano-2,5-Difluorophenylboronic Acid is a high-purity, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its unique molecular structure, which combines a reactive boronic acid group with electron-withdrawing cyano and fluorine substituents, enabling precise cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors who require sophisticated intermediates for developing active pharmaceutical ingredients (APIs), agrochemicals, and organic electronic materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex biaryl structures found in novel drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the difluoro and cyano groups contribute to biological activity and stability.
• Material Science Research: Serves as a monomer or building block for creating functional polymers, liquid crystals, and organic semiconductors.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and sensors due to its boronic acid group's affinity for diols.
• Catalyst Ligand Synthesis: Acts as a starting material for synthesizing specialized ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity boronic acid reagents.

Basic Information

Product Name	4-Cyano-2,5-Difluorophenylboronic Acid
CAS No.	1628442-75-0
Molecular Formula	C7H4BF2NO2
Molecular Weight	182.93 g/mol
Synonyms	(4-Cyano-2,5-difluorophenyl)boronic acid; 2,5-Difluoro-4-cyanophenylboronic acid; 4-Cyano-2,5-difluorobenzeneboronic acid; Boronic acid, B-(4-cyano-2,5-difluorophenyl)-; 1628442-75-0; 4-CN-2,5-F2-PhB(OH)2
EINECS	Contact for details

Quality Control

Every batch of 4-Cyano-2,5-Difluorophenylboronic Acid is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and batch-to-batch consistency suitable for demanding research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.