Description

2-(4,4-Difluoropiperidin-1-Yl)Acetic Acid is a high-purity, versatile piperidine derivative featuring a difluorinated ring and a carboxylic acid functional group. This compound is a critical building block in modern synthetic chemistry, valued for its ability to modulate the physicochemical and metabolic properties of target molecules. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoropiperidine moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials that require fluorine-containing monomers for specific performance characteristics.
• Chemical Biology Probes: Utilized as a scaffold for designing molecular probes and tool compounds to study enzyme function and biological pathways.

Basic Information

Item	Detail
Product Name	2-(4,4-Difluoropiperidin-1-Yl)Acetic Acid
CAS No.	1627998-04-2
Molecular Formula	C7H11F2NO2
Molecular Weight	179.16 g/mol
Synonyms	2-(4,4-Difluoropiperidin-1-yl)acetic acid; 2-(4,4-Difluoro-1-piperidinyl)acetic Acid; 4,4-Difluoropiperidine-1-acetic acid; (4,4-Difluoropiperidin-1-yl)acetic acid; 1-Carboxymethyl-4,4-difluoropiperidine; 1627998-04-2; Acetic acid, 2-(4,4-difluoro-1-piperidinyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-(4,4-Difluoropiperidin-1-Yl)Acetic Acid is manufactured under a cGMP-compliant quality management system and undergoes rigorous analytical testing. We ensure compliance with stringent internal specifications, which are aligned with industry standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. The container must be kept tightly sealed due to the compound's nature as a strong acid/organic solvent.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.